methemoglobin reductase การใช้

• The methemoglobin reductase enzyme may be under-produced or absent in certain people that have an inherited mutation.
• In such cases, the enzyme methemoglobin reductase will be able to eventually reactivate methemoglobin by reducing the iron center.
• Infants in this age range are vulnerable because they have not matured enough to produce methemoglobin reductase, an oxygen-carrying molecule.
• This is achieved by providing an artificial electron acceptor ( such as methylene blue or flavin ) for NADPH methemoglobin reductase ( RBCs usually don't have one; the presence of methylene blue allows the enzyme to function at 5?normal levels ).
• Spontaneously formed methemoglobin is normally reduced ( regenerating normal hemoglobin ) by protective enzyme systems, e . g ., NADH methemoglobin reductase ( cytochrome-b5 reductase ) ( major pathway ), NADPH methemoglobin reductase ( minor pathway ) and to a lesser extent the ascorbic acid and glutathione enzyme systems.
• Spontaneously formed methemoglobin is normally reduced ( regenerating normal hemoglobin ) by protective enzyme systems, e . g ., NADH methemoglobin reductase ( cytochrome-b5 reductase ) ( major pathway ), NADPH methemoglobin reductase ( minor pathway ) and to a lesser extent the ascorbic acid and glutathione enzyme systems.